Publication:
Weaving Mitochondrial DNA and Y-Chromosome Variation in the Panamanian Genetic Canvas

Loading...
Thumbnail Image
Publication date
2021-11-29
Reading date
Event date
Start date of the public exhibition period
End date of the public exhibition period
Advisors
Authors of photography
Person who provides the photography
Journal Title
Journal ISSN
Volume Title
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Export
Research Projects
Organizational Units
Journal Issue
Abstract
The Isthmus of Panama was a crossroads between North and South America during the continent's first peopling (and subsequent movements) also playing a pivotal role during European colonization and the African slave trade. Previous analyses of uniparental systems revealed significant sex biases in the genetic history of Panamanians, as testified by the high proportions of Indigenous and sub-Saharan mitochondrial DNAs (mtDNAs) and by the prevalence of Western European/northern African Y chromosomes. Those studies were conducted on the general population without considering any self-reported ethnic affiliations. Here, we compared the mtDNA and Y-chromosome lineages of a new sample collection from 431 individuals (301 males and 130 females) belonging to either the general population, mixed groups, or one of five Indigenous groups currently living in Panama. We found different proportions of paternal and maternal lineages in the Indigenous groups testifying to pre-contact demographic events and genetic inputs (some dated to Pleistocene times) that created genetic structure. Then, while the local mitochondrial gene pool was marginally involved in post-contact admixtures, the Indigenous Y chromosomes were differentially replaced, mostly by lineages of western Eurasian origin. Finally, our new estimates of the sub-Saharan contribution, on a more accurately defined general population, reduce an apparent divergence between genetic and historical data.
Doctoral program
Related publication
Research projects
info:eu-repo/grantAgreement/EC/H2020/648535
Description
Bibliographic reference
Genes 2021, 12(12), 1921
Photography rights