RT Journal Article
T1 Weaving Mitochondrial DNA and Y-Chromosome Variation in the Panamanian Genetic Canvas
A1 Rambaldi Migliore, Nicola
A1 Colombo, Giulia
A1 Capodiferro, Marco
A1 García Montón, Alejandro
A1 Aram, Bethany
K1 Sex bias
K1 Indigenous American lineages and genetic history
K1 Uniparental transmission
K1 Phylogeography
K1 Y chromosome
K1 Mitochondrial DNA
K1 Isthmus of Panama
AB The Isthmus of Panama was a crossroads between North and South America during the continent's first peopling (and subsequent movements) also playing a pivotal role during European colonization and the African slave trade. Previous analyses of uniparental systems revealed significant sex biases in the genetic history of Panamanians, as testified by the high proportions of Indigenous and sub-Saharan mitochondrial DNAs (mtDNAs) and by the prevalence of Western European/northern African Y chromosomes. Those studies were conducted on the general population without considering any self-reported ethnic affiliations. Here, we compared the mtDNA and Y-chromosome lineages of a new sample collection from 431 individuals (301 males and 130 females) belonging to either the general population, mixed groups, or one of five Indigenous groups currently living in Panama. We found different proportions of paternal and maternal lineages in the Indigenous groups testifying to pre-contact demographic events and genetic inputs (some dated to Pleistocene times) that created genetic structure. Then, while the local mitochondrial gene pool was marginally involved in post-contact admixtures, the Indigenous Y chromosomes were differentially replaced, mostly by lineages of western Eurasian origin. Finally, our new estimates of the sub-Saharan contribution, on a more accurately defined general population, reduce an apparent divergence between genetic and historical data.
PB Multidisciplinary Digital Publishing Institute (MDPI)
YR 2021
FD 2021-11-29
LK http://hdl.handle.net/10433/15274
UL http://hdl.handle.net/10433/15274
LA en
NO Genes 2021, 12(12), 1921
NO Universidad Pablo Olavide. Departamento de Geografía, Historia y Filosofía
DS RIO
RD May 9, 2026