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dc.contributor.authorBaena Pérez, Daniel
dc.contributor.authorAtienza, Mercedes 
dc.contributor.authorCantero Lorente, José Luis 
dc.date.accessioned2021-10-11T09:05:20Z
dc.date.available2021-10-11T09:05:20Z
dc.date.issued2021-09-24
dc.identifier.citationNeurobiology of Learning and Memory, 185, 107529es_ES
dc.identifier.doi10.1016/j.nlm.2021.107529
dc.identifier.urihttp://hdl.handle.net/10433/11646
dc.description.abstractThere is evidence suggesting that online consolidation during retrieval-mediated learning interacts with offline consolidation during subsequent sleep to transform memory. Here we investigate whether this interaction persists when retrieval-mediated learning follows post-training sleep and whether the direction of this interaction is conditioned by the quality of encoding resulting from manipulation of the amount of sleep on the previous night. The quality of encoding was determined by computing the degree of similarity between EEG-activity patterns across restudy of face pairs in two groups of young participants, one who slept the last 4 h of the pre-training night, and another who slept 8 h. The offline consolidation was assessed by computing the degree of coupling between slow oscillations (SOs) and spindles (SPs) during post-training sleep, while the online consolidation was evaluated by determining the degree of similarity between EEG-activity patterns recorded during the study phase and during repeated recognition of either the same face pair (i.e., specific similarity) or face pairs sharing sex and profession (i.e., categorical similarity) to evaluate differentiation and generalization, respectively. The study and recognition phases were separated by a night of normal sleep duration. Mixed-effects models revealed that the stability of neural encoding moderated the relationship between sleep- and retrieval-mediated consolidation processes over left frontal regions. For memories showing lower encoding stability, the enhanced SO-SP coupling was associated with increased reinstatement of category-specific encoding-related activity at the expense of content-specific activity, whilst the opposite occurred for memories showing greater encoding stability. Overall, these results suggest that offline consolidation during post-training sleep interacts with online consolidation during retrieval the next day to favor the reorganization of memory contents, by increasing specificity of stronger memories and generalization of the weaker ones.es_ES
dc.description.sponsorshipLaboratory of Functional Neuroscience, Universidad Pablo de Olavide, Seville 41013, Spaines_ES
dc.description.sponsorshipCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Spaines_ES
dc.language.isoenes_ES
dc.publisherElsevieres_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEEG pattern similarityes_ES
dc.subjectMemory consolidationes_ES
dc.subjectDifferentiationes_ES
dc.subjectGeneralizationes_ES
dc.subjectSleepes_ES
dc.subjectSlow oscillation-spindle couplinges_ES
dc.titleStability of neural encoding moderates the contribution of sleep and repeated testing to memory consolidationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsopenAccesses_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional