Kainate receptors: from synaptic activity to disease
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Kainate receptorSynaptic activity
Disease
Epilepsy
Publication date
2021-06-18Abstract
Kainate receptors (KARs) are glutamate receptors that participate in the
postsynaptic transmission of information and in the control of neuronal
excitability, as well as presynaptically modulating the release of the neurotransmitters
GABA and glutamate. These modulatory effects, general follow
a biphasic pattern, with low KA concentrations provoking an increase
in GABA and glutamate release, and higher concentrations mediating a
decrease in the release of these neurotransmitters. In addition, KARs are
involved in different forms of long- and short-term plasticity. Importantly,
altered activity of these receptors has been implicated in different central
nervous system diseases and disturbances. Here, we describe the pre- and
postsynaptic actions of KARs, and the possible role of these receptors in
disease, a field that has seen significant progress in recent years.