Gallardo Palomo, PaolaSalas-Pino, SilviaDaga, Rafael2025-12-172025-12-172021-06-06Curr Genet . 2021 Dec;67(6):849-85510.1007/s00294-021-01191-2https://hdl.handle.net/10433/25240Proyectos de investigación Ministerio de Ciencia, Innovación y Universidades PGC2018-099849-B-I00 Junta de Andalucía-FEDER-UPO grant: UPO-1264663Temperature fluctuation is one of the most frequent threats to which organisms are exposed in nature. The activation of gene expression programs that trigger the transcription of heat stress-protective genes is the main cellular response to resist high temperatures. In addition, reversible accumulation and compartmentalization of thermosensitive proteins in high-order molecular assemblies are emerging as critical mechanisms to ensure cellular protection upon heat stress. Here, we summarize representative examples of membrane-less intracellular bodies formed upon heat stress in yeasts and human cells and highlight how protein aggregation can be turned into a cytoprotective mechanism.application/pdfenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Protein aggregationCondensateHeat stressNucleolar ringjournal articleopen access