%0 Journal Article
%A Andrade Talavera, Yuniesky
%A Benito, Itziar
%A Casañas, Juan José
%A Rodríguez-Moreno, Antonio
%A Montesinos, María Luz
%T Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
%D 2015
%U https://hdl.handle.net/10433/23690
%X Down's syndrome (DS) is the most prevalent genetic intellectual disability. Memory deficits significantly contribute to the cognitive dysfunction in DS. Previously, we discovered that mTOR-dependent local translation, a pivotal process for some forms of synaptic plasticity, is deregulated in a DS mouse model. Here, we report that these mice exhibit deficits in both synaptic plasticity (i.e., BDNF-long term potentiation) and the persistence of spatial long-term memory. Interestingly, these deficits were fully reversible using rapamycin, a Food and Drug Administration-approved specific mTOR inhibitor; therefore, rapamycin may be a novel pharmacotherapy to improve cognition in DS.
%K BDNF-LTP
%K Barnes maze
%K ERK
%K MTOR
%K Pharmacotherapy
%K Rapamycin
%K Synaptic plasticity
%K Trisomy 21
%K Ts1Cje
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