RT Journal Article T1 Training effects of traditional versus cluster set configuration with and without blood flow restriction A1 Cornejo Daza, Pedro Jesús A1 Sánchez-Valdepeñas Mateos-Aparicio, Juan A1 Rodiles Guerrero, Luis A1 Boullosa, Daniel A1 León-Prados, Juan Antonio A1 Wernbom, Mathias A1 Pareja Blanco, Fernando K1 Arterial Occlusion Pressure K1 Neural adaptations K1 Inter-Set K1 Structural adaptations K1 Training prescription K1 Velocity-based training AB Purpose: This study compared the effects of four different resistance training (RT) programs that differed in the set configuration (cluster vs. traditional) and the blood flow condition [free-flow (FF) vs. blood flow restriction (BFR)] on strength, neuromuscular and hypertrophic adaptations.Methods: Forty-two resistance-trained males were randomly assigned into four protocols that differed in the set configuration (TRA: without rest between repetitions vs. CLU: 30 s rest every 2 repetitions) and in the blood flow condition [FF vs. BFR (50% of arterial occlusion pressure)]. Subjects followed an 8-week RT program, twice per week, with similar intensity (55%-65% 1RM), sets (3), repetitions per set (10-6), and resting time (2 minutes) in the full-squat (SQ) exercise. Before and after the RT program, they were evaluated for: 1) muscle size of the vastus lateralis; 2) vertical jump; 3) maximal isometric contraction; 4) progressive loading test; and 5) fatigue test.Results: BFR-TRA and FF-CLU induced greater increases in 1RM, and velocity against submaximal loads than FF-TRA and BFR-CLU (BFR × time and CLU × time interactions, p = 0.02). The TRA protocols showed greater increases in maximal isometric force than CLU (CLU × time interaction, p = 0.03). BFR did not enhance jump performance unlike the FF protocols (p < 0.01). The TRA protocols induced greater hypertrophy in the distal region of the vastus lateralis than CLU protocols (CLU × time interaction, p = 0.04), with BFR-TRA producing the greatest gains in all vastus lateralis sections.Conclusions: The different combinations of set configurations and blood flow conditions resulted in highly specific adaptations that illustrate the potential of adaptation for each protocol. The divergent underlying mechanisms of CLU and BFR methodologies may offset each other when combined. PB Madison, Wis., American College of Sports Medicine YR 2024 FD 2024-11-06 LK https://hdl.handle.net/10433/22358 UL https://hdl.handle.net/10433/22358 LA en NO Cornejo-Daza PJ, Sánchez-Valdepeñas J, Rodiles-Guerrero L, Boullosa D, León-Prados JA, Wernbom M, Pareja-Blanco F. Training Effects of Traditional versus Cluster Set Configuration with and without Blood Flow Restriction. Med Sci Sports Exerc. 2024 Nov 6. doi: 10.1249/MSS.0000000000003600. Epub ahead of print. PMID: 39501490. NO Faculty of Sport Sciences. Department of Sports and Computers Sciences. Universidad Pablo de Olavide, Seville DS RIO RD Jun 2, 2026