RT Journal Article
T1 Biological warfare between two bacterial viruses in a defense archipelago sheds light on the spread of CRISPR-Cas systems
A1 Rubio Valle, Alejandro
A1 Garzón, Andrés
A1 Moreno Rodríguez, Antonio
A1 Pérez-Pulido, Antonio J.
K1 CRISPR-Cas
K1 PAM escape
K1 Antiviral system
K1 Bacteriophage
K1 Defense archipelago
K1 Defense system
K1 Genomic island
K1 Microbial genomics
K1 Pangenome
K1 Phage-plasmid
AB CRISPR-Cas systems are adaptive immunity systems of bacteria and archaea that prevent infection by viruses and other external mobile genetic elements. It is currently known that these defense systems can be co-opted by the same viruses. We have found one of these viruses in the opportunistic pathogen Acinetobacter baumannii, and the same system has been also found in an integration hotspot of the bacterial genome that harbors other multiple defense systems. The CRISPR-Cas system appears to especially target another virus that could compete with the system itself for the same integration site. This virus is prevalent in strains of the species belonging to the so-called Global Clone 2, which causes the most frequent outbreaks worldwide. Knowledge of this viral warfare involving antiviral systems could be useful in the fight against infections caused by bacteria, and it would also shed light on how CRISPR-Cas systems expand in bacteria.
PB Cell Press
YR 2024
FD 2024-12-24
LK https://hdl.handle.net/10433/25480
UL https://hdl.handle.net/10433/25480
LA en
NO Alejandro Rubio, Andrés Garzón, Antonio Moreno-Rodríguez, Antonio J. Pérez-Pulido, Biological warfare between two bacterial viruses in a defense archipelago sheds light on the spread of CRISPR-Cas systems, Cell Reports, Volume 43, Issue 12, 2024, 115085, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2024.115085
NO Universidad Pablo de Olavide. Departamento de Biología Molecular e Ingeniería Bioquímica
DS RIO
RD Apr 24, 2026