RT Journal Article
T1 Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition
A1 Villa Consuegra, Sergio
A1 Álvarez Tallada, Víctor
A1 Jiménez, Juan
K1 Natural sciences
K1 Biological sciences
K1 Biochemistry
K1 Molecular biology
K1 Cell biology
AB During meiosis, faithful chromosome segregation requires monopolar spindle microtubule-kinetochore arrays in MI to segregate homologous chromosomes, but bipolar in MII to segregate sister chromatids. Using fission yeasts, we found that the universal Aurora B kinase localizes to kinetochores in metaphase I and in the mid-spindle during anaphase I, as in mitosis; but in the absence of an intervening S phase, the importin α Imp1 propitiates its release from the spindle midzone to re-localize at kinetochores during meiotic interkinesis. We show that “error-correction” activity of kinetochore re-localized Aurora B becomes essential to erase monopolar arrangements from anaphase I, a prerequisite to satisfy the spindle assembly checkpoint (SAC) and to generate proper bipolar arrays at the onset of MII. This microtubule-kinetochore resetting activity of Aurora B at the MI-MII transition is required to prevent chromosome missegregation in meiosis II, a type of error often associated with birth defects and infertility in humans.
PB Elsevier
YR 2023
FD 2023
LK https://hdl.handle.net/10433/20078
UL https://hdl.handle.net/10433/20078
LA en
NO iScience Volume 26, Issue 11, 17 November 2023, 108339
NO Universidad Pablo de Olavide
NO Centro Andaluz de Biología del Desarrollo
DS RIO
RD May 10, 2026