RT Journal Article
T1 Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.
A1 Daga, Rafael
A1 Salas-Pino, Silvia
A1 Flor-Parra, Ignacio
A1 Iglesias Romero, Ana Belén
A1 Lucena Rafael, 
A1 Jiménez, Juan
K1 Schizosaccharomyces pombe
K1 Fission yeast
K1 Nucleocytoplasmic transport
K1 Imp1
K1 vNEBD
K1 Nuclear envelope
K1 Meiosis
K1 Spindle disassembly
AB In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during "open" mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (MI) are "closed," during which the NE is maintained. Intriguingly, during the second meiotic division (MII), the NE is also maintained, but nuclear and cytoplasmic molecules are mixed similarly to open mitosis, a phenomenon of unknown biological significance called "virtual" NEBD (vNEBD). Here, we show that importin-α-dependent nucleocytoplasmic transport regulates spindle disassembly late in anaphase B at MI, as previously reported for mitosis. At MII, however, spindle dissolution is triggered by vNEBD early in anaphase B, a mechanism that short-circuits the nucleocytoplasmic transport system. We demonstrate that the sequential action of these two spindle disassembly systems regulates the spatiotemporal order and ploidy of the meiotic products.
PB Cell Press
YR 2018
FD 2018-04-24
LK https://hdl.handle.net/10433/25242
UL https://hdl.handle.net/10433/25242
LA en
NO Cell Rep . 2018 Apr 24;23(4):933-941
NO Departamento de Biología Molecular e Ingeniería Bioquímica. Centro Andaluz de Biología del Desarrollo
DS RIO
RD Apr 23, 2026