RT Journal Article
T1 Improving type 2 diabetes mellitus glycaemic control through lifestyle modification implementing diet intervention: a systematic review and meta‑analysis.
A1 García‑Molina, Laura
A1 Lewis‑Mikhael, Anne‑Mary
A1 Riquelme‑Gallego, Blanca
A1 Cano‑Ibáñez, Naomi
A1 Oliveras-López, María-Jesús
A1 Bueno‑Cavanillas, Aurora
K1 Diet
K1 Glycaemic control
K1 Lifestyle intervention
K1 Meta-analysis
K1 Systematic review
K1 Type 2 diabetes mellitus
AB PurposeType 2 diabetes mellitus represents a significant health problem. Many studies have reported that intensive nutritional intervention by itself or in addition to medications is the best method to improve glycaemic control in type 2 diabetes mellitus. However, in clinical practice, dietary education is not implemented as an integral part in the management of type 2 diabetes mellitus. The purpose of this systematic review and meta-analysis is to analyse the scientific evidence concerning the role of nutritional intervention in the glycaemic control of type 2 diabetes mellitus.MethodsWe searched Pubmed, Scopus, Cochrane Library and Web of Science databases from inception till May 2019 for randomised controlled trials (RCTs) that include dietary interventions in the management of patients with type 2 diabetes mellitus.ResultsA total of 28 studies were included. Our results demonstrated that lifestyle interventions significantly lowered glycosylated haemoglobin (HbA1c) levels compared to the usual care for patients with type 2 diabetes mellitus, overall weighted mean difference, WMD = − 0.51 (− 0.67, − 0.35). Strategies combining individualized and group-based activities were the most effective, WMD = − 0.95 (− 1.24, − 0.66). Most of stratified analyses did not totally resolve heterogeneity, but improvement in HbA1c levels has been consistently observed.ConclusionsThe available evidence from RCTs shows that lifestyle intervention is more effective than the standard care regarding the glycaemic control of type 2 diabetic patients, particularly when there is a weight loss. It is time to translate this evidence to the primary health care practice. The protocol of the present systematic review was registered in PROSPERO, registration number CRD42018090469.
PB Springer Nature
YR 2019
FD 2019-09-18
LK https://hdl.handle.net/10433/24875
UL https://hdl.handle.net/10433/24875
LA en
NO García-Molina, L., Lewis-Mikhael, AM., Riquelme-Gallego, B. et al. Improving type 2 diabetes mellitus glycaemic control through lifestyle modification implementing diet intervention: a systematic review and meta-analysis. Eur J Nutr 59, 1313–1328 (2020). https://doi.org/10.1007/s00394-019-02147-6
NO Department of Preventive Medicine and Public Health, University of Granada, Avenida de la Investigación, 11, 18016 Granada, Spain
NO CIBER Epidemiología y Salud Pública (CIBERESP), Avenida Monforte de Lemos, 3‑5, 28029 Madrid, Spain
NO Department of Obstetrics and Gynecology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada
NO High Institute of Pubic Health, Alexandria University, 165 El‑Horreya Avenue – El‑Ibrahimia, Alexandria, Egypt
NO Fundación para la Investigación Biosanitaria de Andalucía Oriental (FIBAO), Avenida de Madrid, 15, 18018 Granada, Spain
NO Department of Molecular Biology and Biochemical Engineering, University Pablo de Olavide, Carretera de Utrera, Km 1, 41013 Seville, Spain
NO Instituto de Investigación Biosanitaria de Granada (ibs.Granada), Servicio Andaluz de Salud/Universidad de Granada, Avenida de Madrid, 15, 18018 Granada, Spain
DS RIO
RD May 6, 2026