RT Journal Article
T1 Persimmon Fiber-Rich ingredients promote anti-inflammatory responses and the growth of beneficial anti-inflammatory firmicutes species from the human colon
A1 López Bermudo, Lucía
A1 Moreno-Chamba, Bryan
A1 Salazar-Bermeo, Julio
A1 Hayward, Nicholas J
A1 Morris, Amanda
A1 Duncan, Gary J
A1 Russell, Wendy R
A1 Cárdenas García, Antonio Manuel
A1 Ortega de la Torre, María de los Ángeles
A1 Escudero López, Blanca
A1 Berná, Genoveva
A1 Martí Bruña, Nuria
A1 Duncan, Sylvia H
A1 Neacsu, Madalina
A1 Martín, Franz
K1 Dietary fiber
K1 Faecalibacterium prausntizii
K1 Eubacterium eligens
K1 Pectins
K1 Anti-inflammatory activity
K1 Butyrate
AB Persimmon fruit processing-derived waste and by-products, such as peels and pomace, are important sources of dietary fiber and phytochemicals. Revalorizing these by-products couldhelp promote circular nutrition and agricultural sustainability while tackling dietary deficiencies and chronic diseases. In this study, fiber-rich fractions were prepared from the by-products of Sharoni and Brilliant Red persimmon varieties. These fractions were quantified for their phenolic composition and assessed for their ability to promote the growth of beneficial human colonic Firmicutes species and for their in vitro anti-inflammatory potential. Gallic and protocatechuic acids, delphinidin, and cyanidin were the main phenolics identified. Faecalibacterium prausnitzii strains showed significantly higher growth rates in the presence of the Brilliant Red fraction, generating more than double butyrate as a proportion of the total short-chain fatty acids (39.5% vs. 17.8%) when compared to glucose.The fiber-rich fractions significantly decreased the inflammatory effect of interleukin-1β in Caco-2 cells, and the fermented fractions (both from Sharoni and Brilliant Red) significantly decreased the inflammatory effect of interleukin-6 and tumor necrosis factor-α in the RAW264.7 cells. Therefore, fiber-rich fractions from persimmon by-products could be part of nutritional therapies as they reduce systemic inflammation, promote the growth of beneficial human gut bacteria, and increase theproduction of beneficial microbial metabolites such as butyrate.
AB This research was funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS) Strategic Research Programme (grant number RI-B6-1) and the Spanish Ministerio de Ciencia e Innovación (grant number PID2020-116731RB-C21 to F.M.). JS-B was a recipient of a predoctoral fellowship from Miguel Hernández University (Ayudas a la contratación de personal investigador en formación 2022), Spain. BM-C was a recipient of the Mobility Scholarship from Santander Open Access (Movilidad Internacional UMH 2023—2da convocatoria; 02706/2023), Spain. LL-B was a recipient of an FPU contract (FPU19/04497) from the Ministerio de Educación y Formación Profesional (Spain). LL-B’s stay at The Rowett Institute was supported by a mobility fellowship from the Training Program of the Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), which is funded by the Instituto de Salud Carlos III (Spain).
PB MDPI
YR 2024
FD 2024
LK https://hdl.handle.net/10433/22152
UL https://hdl.handle.net/10433/22152
LA en
NO López-Bermudo, L., Moreno-Chamba, B., Salazar-Bermeo, J., Hayward, N. J., Morris, A., Duncan, G. J., Russell, W. R., Cárdenas, A., Ortega, Á., Escudero-López, B., Berná, G., Martí Bruña, N., Duncan, S. H., Neacsu, M., & Martin, F. (2024). Persimmon Fiber-Rich Ingredients Promote Anti-Inflammatory Responses and the Growth of Beneficial Anti-Inflammatory Firmicutes Species from the Human Colon. Nutrients, 16(15), 2518. https://doi.org/10.3390/nu16152518
NO FECYT -- ESTUDIO DE LAS PROPIEDADES FUNCIONALES Y BIOACTIVAS Y DE SUS EF...
NO Universidad Pablo de Olavide. Departamento de Biología Molecular e Ingeniería Bioquímica.
DS RIO
RD May 9, 2026