%0 Journal Article
%A Gómez-Gonzañez, Elisabeth
%A Nuñez, Nuria
%A Caro, Carlos
%A García-Martín, Maria L.
%A Monje, José Manuel
%A Hamdi, Amel
%A López-Larrubia, Pilar
%A Becerro, Ana
%A Ocaña, Manuel
%T Sodium lanthanide tungstate-based nanoparticles as bimodal probes for T1–T2 magnetic resonance imaging and X-ray computed tomography
%D 2025
%U https://hdl.handle.net/10433/25670
%X Magnetic resonance imaging (MRI) is one of the most used imaging techniques for diagnosis in clinics. Often, magnetically-active substances, called contrast agents (CAs), have to be used, Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Open Access Article. Published on 10 October 2025. Downloaded on 10/10/2025 10:25:41 AM. This article is licensed under a which increase contrast by shortening the longitudinal (T1) (resulting in signal enhancement in T1-weigthed images) and/or transverse (T2) (resulting in signal decay in T2-weighted images) relaxation times of the water protons present in biological tissues. A further strategy to improve diagnostic accuracy is recording both kinds of images (T1-weighted and T2-weighted) using dual T1-T2 CAs, which facilitates the exclusion of false positives. The traditional T1 or T2 contrast agents are not suitable for such a purpose. This paper deals with the development of double sodium lanthanide tungstate-based nanoparticles containing Gd3+ and Dy3+ cations, which are dispersible in physiological media, do not show appreciable in vitro (for human fibroblast cells) and in vivo (for C-elegans) toxicity and present appropriate relaxivity values for their use as a dual T1-T2 contrast agent for magnetic resonance imaging. In addition, they show an excellent X-ray attenuation capacity, thanks, mainly, to their tungsten content, which makes them also useful for X-ray computed tomography. Hence, the developed nanoparticles are ideal multimodal probes to be used as a dual T1-T2 contrast agent for magnetic resonance imaging and as a contrast agent for X-ray computed tomography.
%K Caenorhabditis elegans
%K Lanthanide tungstate
%K Magnetic resonance imaging
%K T1-T2 contrast agents
%K X-ray computed tomography
%K In vivo toxicity
%~