RT Journal Article
T1 Role of PstS in the Pathogenesis of Acinetobacter baumannii Under Microaerobiosis and Normoxia
A1 Jerónimo Pachón, Younes Smani, María Eugenia Pachón-Ibáñez
A1 Gil-Marqués, María Luisa
A1 Labrador Herrera, Gema
A1 Miró Canturri, Andrea
A1 Pachón, Jerónimo
A1 Smani, Younes
A1 Pachón-Ibáñez, María Eugenia
K1 Acinetobacter baumannii
K1 PstS
K1 Microaerobiosis
K1 Virulence factors
AB Acinetobacter baumannii is a successful pathogen responsible for infections with high mortality rate. During the course of infection it can be found in microaerobic environments, which influences virulence factor expression. From a previous transcriptomic analysis of A. baumannii ATCC 17978 under microaerobiosis, we know the gene pstS is overexpressed under microaerobiosis. Here, we studied its role in A. baumannii virulence. pstS loss significantly decreased bacterial adherence and invasion into A549 cells and increased A549 cell viability. pstS loss also reduced motility and biofilm-forming ability of A. baumannii. In a peritoneal sepsis murine model, the minimum lethal dose required by A. baumannii ATCC 17978 ΔpstS was lower compared to the wild type (4.3 vs 3.2 log colony forming units/mL, respectively), and the bacterial burden in tissues and fluids was lower. Thus, the loss of the phosphate sensor PstS produced a decrease in A. baumannii pathogenesis, supporting its role as a virulence factor.
PB Oxford
YR 2020
FD 2020-09-01
LK https://hdl.handle.net/10433/20084
UL https://hdl.handle.net/10433/20084
LA en
NO Departamento de Biología Molecular e Ingeniería Bioquímica
NO Centro Andaluz de Biología del Desarrollo
DS RIO
RD Jun 19, 2026