RT Journal Article
T1 Archaeogenomic distinctiveness of the Isthmo-Colombian area
A1 Capodiferro, Marco Rosario
A1 Aram, Bethany
A1 Raveane, Alessandro
A1 Migliore, Nicola Rambali
A1 Colombo, Giulia
A1 Ongaro, Linda
A1 Rivera-Sandoval, Javier
A1 Mendizábal, Tomás
A1 Hernández Mora, Iosvany
A1 Tribaldos, Maribel
A1 Perego, Ugo
A1 Li Hongjie, Scheib Christiana Lyn
A1 Modi, Alessandra
A1 Gómez-Carballa, Alberto
A1 Grungi, Viola
A1 Lombardo, Gianluca
A1 Hellenthal, Garrett
A1 Pascale, Juan Miguel
A1 Bertolini, Francesco
A1 Grieco, Gaetano
A1 Cereca, Cristina
A1 Lari, Martina
A1 Caramelli, David
A1 Pagani, Luca
A1 Metspalu, Mait
A1 Fredrich, Ronny
A1 Knipper, Corina
A1 Olivieri, Anna
A1 Salas, Antonio
A1 Cooke, Richard
A1 Montinario, Francesco
A1 Motta, Jorge
A1 Torroni, Antonio
A1 Martín, Juan Guillermo
A1 Semino, Ornella
A1 Malhi, Ripan Singh
A1 Achilli, Alessandro
K1 Archaeogenomics
K1 Genomic variation
K1 Population genetics
K1 Archaeology
K1 Anthropology and history
K1 Ancient and modern DNA
K1 Indigenous Americans
K1 Isthmian populations
K1 Central America
K1 Panama
AB The recently enriched genomic history of Indigenous groups in the Americas is still meager concerning continental Central America. Here, we report ten pre-Hispanic (plus two early colonial) genomes and 84 genome-wide profiles from seven groups presently living in Panama. Our analyses reveal that pre-Hispanic demographic events contributed to the extensive genetic structure currently seen in the area, which is also characterized by a distinctive Isthmo-Colombian Indigenous component. This component drives these populations on a specific variability axis and derives from the local admixture of different ancestries of northern North American origin(s). Two of these ancestries were differentially associated to Pleistocene Indigenous groups that also moved into South America, leaving heterogenous genetic footprints. An additional Pleistocene ancestry was brought by a still unsampled population of the Isthmus (UPopI) that remained restricted to the Isthmian area, expanded locally during the early Holocene, and left genomic traces up to the present day.
PB Elsevier
YR 2021
FD 2021-04-01
LK http://hdl.handle.net/10433/10831
UL http://hdl.handle.net/10433/10831
LA en
NO Cell, Volume 184, Issue 7
NO Universidad del Norte
NO Università degli Studi di Pavia
DS RIO
RD May 8, 2026