RT Journal Article T1 Time Course of Recovery From Resistance Exercise With Different Set Configurations A1 Pareja Blanco, Fernando A1 Rodríguez Rosell, David A1 Aagaard, Per A1 Sánchez-Medina, Luis A1 Ribas-Serna, Juan A1 Mora Custodio, Ricardo A1 Otero-Esquina, Carlos A1 Yáñez García, Juan Manuel A1 González Badillo, Juan José K1 Fatigue K1 Hormones K1 Muscle damage K1 Velocitybased training K1 Strength training K1 Muscle failure AB This study analyzed the response to 10 resistance exercise protocols differing in the number of repetitions performed in each set (R) with respect to the maximum predicted number (P). Ten males performed 10 protocols (R(P): 6(12), 12(12), 5(10), 10(10), 4(8), 8(8), 3(6), 6(6), 2(4), and 4(4)). Three sets with 5-minute interset rests were performed in each protocol in bench press and squat. Mechanical muscle function (countermovement jump height and velocity against a 1 m·s−1 load, V1-load) and biochemical plasma profile (testosterone, cortisol, growth hormone, prolactin, IGF-1, and creatine kinase) were assessed at several time points from 24-hour pre-exercise to 48-hour post-exercise. Protocols to failure, especially those in which the number of repetitions performed was high, resulted in larger reductions in mechanical muscle function, which remained reduced up to 48-hour post-exercise. Protocols to failure also showed greater increments in plasma growth hormone, IGF-1, prolactin, and creatine kinase concentrations. In conclusion, resistance exercise to failure resulted in greater fatigue accumulation and slower rates of neuromuscular recovery, as well as higher hormonal responses and greater muscle damage, especially when the maximal number of repetitions in the set was high. PB National Strength and Conditioning Association YR 2020 FD 2020 LK https://hdl.handle.net/10433/25088 UL https://hdl.handle.net/10433/25088 LA en NO Journal of Strength and Conditioning Research 34(10):p 2867-2876 NO Departamento: Deporte e Informática DS RIO RD Apr 25, 2026