RT Journal Article
T1 Europium doped-double sodium bismuth molybdate nanoparticles as contrast agents for luminescence bioimaging and X-ray computed tomography
A1 Calderón Olvera, Roxana Marisol
A1 Nuñez, Nuria
A1 Gonzalez-Mancebo, Daniel
A1 Monje, José Manuel
A1 Muñoz Ruiz, Manuel Jesús
A1 Gomez-Gonzalez, Elisabet
A1 Arroyo, Encarnacion
A1 Torres Herrero, Beatriz
A1 de la Fuente, Jesus M
A1 Ocana, Manuel
K1 Nanoparticles
K1 C. elegans
AB A one-pot method for the synthesis of uniform Eu3+-doped NaBi(MoO4)2 nanoparticles with an ellipsoidal shape and tetragonal crystal structure functionalized with polyacrylic acid is reported for the first time in the literature. The method is based on a homogeneous precipitation reaction from solutions in an ethylene glycol/water medium containing appropriate bismuth, sodium, and molybdate precursors and polyacrylic acid. The luminescence properties (excitation and emission spectra and luminescence lifetime) of such nanoparticles are evaluated for different Eu3+ doping levels, finding an intense red emission for all synthesized samples. The X-ray attenuation properties of the nanoparticles have been also analyzed, which were found to be better than those of a commercially computed tomography contrast agent (iohexol). The dispersibility of the nanoparticles in a physiological medium was also analyzed, finding that they could be well dispersed in a 2-N-morpholinoethanesulfonic acid monohydrate medium (pH = 6.5). Finally, the cell viability of such a phosphor has been analyzed using MIA-PaCa-2 cells and its in vivo toxicity has been evaluated using the nematode Caenorhabditis elegans model finding no significant toxicity in both cases up to a nanoparticle concentration of 100 μg mL−1, which is within the range required for most in vivo applications. The developed Eu3+-doped NaBi(MoO4)2 nanoparticles are, therefore, excellent candidates for their use as bimodal probes for luminescence imaging and X-ray computed tomography.
PB Royal Society of Chemistry
YR 2023
FD 2023-02-15
LK https://hdl.handle.net/10433/23793
UL https://hdl.handle.net/10433/23793
LA en
NO Inorg. Chem. Front., 2023,10, 3202-3212
NO This publication is part of the I + D + I Grant RTI2018-094426-B-I00 and funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. R. M. Calderón-Olvera acknowledges the financial support from the CONACYT-801024 postdoctoral grant. E. Gómez-González acknowledges the financial support from the FPI program (PRE2019-090170). E. Arroyo acknowledges the grant FPU19/00527 funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future”. B. T. is grateful for the FPU predoctoral contract (FPU19/01311) from Ministerio de Educación Cultura y Deporte (Spain). J. M. de la Fuente thanks DGA and Fondos Feder (Bionanosurf E15_17R) and CIBER-Consorcio Centro de Investigación Biomédica en Red (CB16/01/00263), Instituto de Salud Carlos III (Spanish Ministry of Science and Innovation and European Commission, European Regional Development Fund). This research was also funded by the European Commission NextGenerationEU (Regulation EU 2020/2094).
NO Universidad Pablo de Olavide, Departamento de Biología Molecular e Ingeniería Bioquímica
NO Instituto de Ciencia de Materiales de Sevilla (CSIC-Universidad de Sevilla)
NO Instituto de Nanociencia y Materiales de Aragón (CSIC-Universidad de Zaragoza) and CIBER-BBN
DS RIO
RD May 6, 2026