RT Journal Article
T1 Levels of Plasma Coenzyme Q10 Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly
A1 Rocío de la Bella-Garzón, 
A1 Fernández-Portero, Cristina
A1 Alarcón, David
A1 García Amián, Josué
A1 López-Lluch, Guillermo
K1 Coenzyme Q10
K1 Ubiquinone
K1 Aging
K1 Health
K1 Fragility
K1 Cholesterol
AB Coenzyme Q10 (CoQ10) is an essential factor for mitochondrial activity and antioxidant protection of cells, tissues and plasma lipoproteins. Its deficiency has been associated with aging progression in animals and humans. To determine if CoQ10 levels in plasma can be associated with frailty in elderly people (aged > 65), we studied the relationship of CoQ10 levels in blood with other parameters in plasma and with the physical activity and capacity in aged people. Our results indicate that high CoQ10 levels are directly associated with lower cardiovascular risk measured by the quotient total cholesterol/HDL cholesterol. Furthermore, high CoQ10 levels were found in people showing higher physical activity, stronger muscle capacity. CoQ10 also showed a strong inverse relationship with sedentarism and the up and go test, which is considered to be a frailty index. Interestingly, we found gender differences, indicating stronger correlations in women than in men. The importance of the maintenance of CoQ10 levels in elderly people to avoid sarcopenia and frailty in elderly people is discussed.
PB MDPI
YR 2022
FD 2022-01-29
LK https://hdl.handle.net/10433/20025
UL https://hdl.handle.net/10433/20025
LA en
NO Antioxidants 2022, 11, 279
NO CONSEJERIA DE CONOCIMIENTO, INVESTIGACIÓN Y UNIVERSIDAD; UPO-1259581; Proyectos I+D+i; Estudio de la influencia de la actividad física en la salud y la capacidad cognitiva durante el envejecimiento UPO-1259581; Proyectos I+D+i
NO Departamento de Fisiología, Anatomía y Biología Celular, Centro Andaluz de Biología del Desarrollo y Departamento de Antropología Social, Psicología Básica y Salud Pública.
DS RIO
RD May 8, 2026