RT Journal Article T1 Occurrence of melatonin and indolic compounds derived from L-tryptophan yeast metabolism in fermented wort and commercial beers A1 Fernández-Cruz, Edwin A1 Carrasco-Galán, Fernando A1 Cerezo-López, Ana B. A1 Valero Blanco, Eva María A1 Morcillo-Parra, Mª Ángeles A1 Beltran, Gemma A1 Torija, María-Jesús A1 Troncoso, Ana M. A1 García-Parrilla, Mª Carmen K1 Melatonin K1 3-Indoleacetic acid K1 Beer K1 Bioactive K1 HRMS K1 Fermentation K1 Saccharomyces cerevisiae AB Melatonin and serotonin are bioactive compounds present in foods and beverages and related to neuroprotection and anti-angiogenesis, among other activities. They have been described in wines and the role of yeast in their formation is clear. Thus, this study evaluates the content of these bioactives and other related indolic compounds in beer. For this purpose, commercial beers were analyzed by a validated UHPLC-HRMS method and sample treatment optimized due to the low concentrations expected. Moreover, a wort was fermented with different commercial beer yeast (Abbaye, Diamond, SafAle, SafLager) in order to monitor the formation of these bioactives during the elaboration process. Results show that indolic compounds such as N-acetylserotonin and 3-indoleacetic acid are produced during the alcoholic fermentation of wort. Moreover, the occurrence of four indolic compounds (5-hydroxytryptophan, N-acetylserotonin, 3-indoleacetic acid, L-tryptophan ethyl ester) in commercial beers is reported for the first time. PB Elsevier YR 2020 FD 2020-06-20 LK https://hdl.handle.net/10433/25332 UL https://hdl.handle.net/10433/25332 LA en NO Food Chemistry 331 (2020) 127192 NO Universidad Pablo de Olavide. Departamento de Biología Molecular e Ingeniería Bioquímica DS RIO RD Jun 18, 2026