RT Dissertation/Thesis
T1 New players of the mitotic checkpoint in S. pombe
A1 Iglesias Romero, Ana Belén
K1 Biotecnología
K1 Bioquímica
K1 Genética
AB The Mitotic Checkpoint or Spindle Assembly Checkpoint (SAC) is a surveillance mechanism that contributes to the preservation of genomic stability by delaying the timing of mitotic exit until all chromosomes are properly attached to the mitotic spindle apparatus. A defective SAC results in embryonic lethality and premature ageing in mouse models. In human cell culture, a defective SAC leads to a drastic increase in the appearance of aneuploidy. During cancer evolution, aneuploidies are thought to allow the clonal expansion of those tumour cells with chromosome combinations that provide increased proliferation potential, invasiveness as well as drug resistance among others. In this thesis, using the fission yeast as a model organism, we have explored a mechanism by which Mitogen-Activated Protein kinase (MAPK) pathways might regulate the activity of the SAC.
YR 2018
FD 2018
LK http://hdl.handle.net/10433/6508
UL http://hdl.handle.net/10433/6508
LA en
NO Programa de Doctorado en Biotecnología, Ingeniería y Tecnología Química
NO Línea de Investigación: Biología Celular, Molecular e Ingeniería Genética
NO Clave Programa: DBI
NO Código Línea: 8
NO Universidad Pablo de Olavide de Sevilla. Departamento de Biología Molecular e Ingeniería Bioquímica
DS RIO
RD May 22, 2026