RT Journal Article
T1 Reversible protein aggregation as cytoprotective mechanism against heat stress.
A1 Gallardo Palomo, Paola
A1 Salas-Pino, Silvia
A1 Daga, Rafael
K1 Protein aggregation
K1 Condensate
K1 Heat stress
K1 Nucleolar ring
AB Temperature fluctuation is one of the most frequent threats to which organisms are exposed in nature. The activation of gene expression programs that trigger the transcription of heat stress-protective genes is the main cellular response to resist high temperatures. In addition, reversible accumulation and compartmentalization of thermosensitive proteins in high-order molecular assemblies are emerging as critical mechanisms to ensure cellular protection upon heat stress. Here, we summarize representative examples of membrane-less intracellular bodies formed upon heat stress in yeasts and human cells and highlight how protein aggregation can be turned into a cytoprotective mechanism.
PB Springer
YR 2021
FD 2021-06-06
LK https://hdl.handle.net/10433/25240
UL https://hdl.handle.net/10433/25240
LA en
NO Curr Genet . 2021 Dec;67(6):849-855
NO Proyectos de investigaciónMinisterio de Ciencia, Innovación y Universidades PGC2018-099849-B-I00Junta de Andalucía-FEDER-UPO grant: UPO-1264663
NO Departamento de Biología Molecular e Ingeniería Bioquímica. Centro Andaluz de Biología del Desarrollo
DS RIO
RD Apr 23, 2026