%0 Journal Article
%A Gallardo Palomo, Paola
%A Salas-Pino, Silvia
%A Daga, Rafael
%T Reversible protein aggregation as cytoprotective mechanism against heat stress.
%D 2021
%U https://hdl.handle.net/10433/25240
%X Temperature fluctuation is one of the most frequent threats to which organisms are exposed in nature. The activation of gene expression programs that trigger the transcription of heat stress-protective genes is the main cellular response to resist high temperatures. In addition, reversible accumulation and compartmentalization of thermosensitive proteins in high-order molecular assemblies are emerging as critical mechanisms to ensure cellular protection upon heat stress. Here, we summarize representative examples of membrane-less intracellular bodies formed upon heat stress in yeasts and human cells and highlight how protein aggregation can be turned into a cytoprotective mechanism.
%K Protein aggregation
%K Condensate
%K Heat stress
%K Nucleolar ring
%~