RT Journal Article
T1 Training effects of traditional versus cluster set configuration with and without blood flow restriction
T2 
A1 Cornejo Daza, Pedro Jesús
A1 Sánchez-Valdepeñas Mateos-Aparicio, Juan
A1 Rodiles Guerrero, Luis
A1 Boullosa, Daniel
A1 León-Prados, Juan Antonio
A1 Wernbom, Mathias
A1 Pareja Blanco, Fernando
K1 Arterial occlusion pressure
K1 Neural adaptations
K1 Inter-set
K1 Structural  adaptations
K1 Training prescription
K1 Velocity-based training
AB Purpose: This study compared the effects of four different resistance training (RT) programs that differed in the set configuration (cluster vs traditional) and the blood flow condition (free-flow [FF] vs blood flow restriction [BFR]) on strength, neuromuscular and hypertrophic adaptations.Methods: Forty-two resistance-trained males were randomly assigned into four protocols that differed in the set configuration (TRA: without rest between repetitions versus CLU: 30 s rest every two repetitions) and in the blood flow condition (FF vs BFR [50% of arterial occlusion pressure]). Subjects followed an 8-week RT program, twice per week, with similar intensity (55%-65% 1RM), sets (3), repetitions per set (10-6), and resting time (2 min) in the full-squat (SQ) exercise. Before and after the RT program, they were evaluated for: 1) muscle size of the vastus lateralis ; 2) vertical jump; 3) maximal isometric contraction; 4) progressive loading test; and 5) fatigue test.Results: BFR-TRA and FF-CLU induced greater increases in 1RM, and velocity against submaximal loads than FF-TRA and BFR-CLU (BFR-time and CLU-time interactions, P = 0.02). The TRA protocols showed greater increases in maximal isometric force than CLU (CLU-time interaction, P = 0.03). BFR did not enhance jump performance unlike the FF protocols ( P < 0.01). The TRA protocols induced greater hypertrophy in the distal region of the vastus lateralis than CLU protocols (CLU-time interaction, P = 0.04), with BFR-TRA producing the greatest gains in all vastus lateralis sections.Conclusions: The different combinations of set configurations and blood flow conditions resulted in highly specific adaptations that illustrate the potential of adaptation for each protocol. The divergent underlying mechanisms of CLU and BFR methodologies may offset each other when combined.
PB Lippincott Williams & Wilkins
YR 2025
FD 2025-04-01
LK https://hdl.handle.net/10433/23891
UL https://hdl.handle.net/10433/23891
LA en
NO Cornejo-Daza, P. J., Sánchez-Valdepeñas, J., Rodiles-Guerrero, L., Boullosa, D., León-Prados, J. A., Wernbom, M., & Pareja-Blanco, F. (2025). Training Effects of Traditional versus Cluster Set Configuration with and without Blood Flow Restriction. Medicine and science in sports and exercise, 57(4), 668–679.
NO Centro de Investigación en Rendimiento Físico y Deportivo (CIRFD)
DS RIO
RD May 24, 2026