RT Journal Article
T1 Kainate receptor-mediated depression of glutamatergic transmission involving protein kinase A in the lateral amygdala
A1 Negrete Diaz, Jose Vicente
A1 Duque Feria, Paloma
A1 Andrade Talavera, Yuniesky
A1 Carrión Reinoso, Miriam
A1 Flores Álvarez, Gonzalo
A1 Rodríguez-Moreno, Antonio
K1 Amygdala
K1 Glutamate
K1 Kainate receptors
K1 Pre-synaptic
K1 Protein kinase A
AB Kainate receptors (KARs) have been described as modulators of synaptic transmission at different synapses. However, this role of KARs has not been well characterized in the amygdala. We have explored the effect of kainate receptor activation at the synapse established between fibers originating at medial geniculate nucleus and the principal cells in the lateral amygdala. We have observed an inhibition of evoked excitatory postsynaptic currents (eEPSCs) amplitude after a brief application of KARs agonists KA and ATPA. Paired-pulse recordings showed a clear pair pulse facilitation that was enhanced after KA or ATPA application. When postsynaptic cells were loaded with BAPTA, the depression of eEPSC amplitude observed after the perfusion of KAR agonists was not prevented. We have also observed that the inhibition of the eEPSCs by KARs agonists was prevented by protein kinase A but not by protein kinase C inhibitors. Taken together our results indicate that KARs present at this synapse are pre-synaptic and their activation mediate the inhibition of glutamate release through a mechanism that involves the activation of protein kinase A.
PB Wiley
YR 2012
FD 2012
LK https://hdl.handle.net/10433/23672
UL https://hdl.handle.net/10433/23672
LA en
NO Negrete-Díaz, J.V., Duque-Feria, P., Andrade-Talavera, Y., Carrión, M., Flores, G. and Rodríguez-Moreno, A. (2012), Kainate receptor-mediated depression of glutamatergic transmission involving protein kinase A in the lateral amygdala. Journal of Neurochemistry, 121: 36-43. https://doi.org/10.1111/j.1471-4159.2012.07665.x
NO Departamento de Fisiología, Anatomía y Biología Celular
DS RIO
RD May 3, 2026