RT Journal Article T1 Mechanical, Neuromuscular, and Hypertrophic Adaptations Through Different Velocity Loss Thresholds With Moderate Loads in Full Squat A1 Sánchez-Valdepeñas Mateos-Aparicio, Juan A1 Cornejo Daza, Pedro Jesús A1 Rodiles Guerrero, Luis A1 Sánchez-Moreno, Miguel A1 Alegre, Luis M. A1 Alcázar, Julián A1 Pareja Blanco, Fernando K1 Fatigue K1 Level of effort K1 Muscle hypertrophy K1 Resistance training K1 Training prescription K1 Velocity-based training AB This study aimed to compare the effects of 4 different velocity loss (VL) thresholds (0, 10, 20 and 40%) on hypertrophic, mechanical, and neuromuscular adaptations during a full-squat (SQ) training program, using loads ranging from 55 to 70% of 1-repetition maximum (1RM). Fifty-one moderately resistance-trained men were randomly assigned to 4 training groups, which differed in the VL threshold achieved within the set (VL0, VL10, VL20, and VL40). Subjects completed 16 SQ sessions (2 per week). Pre- and post-intervention assessments included the following: (a) cross-sectional area (CSA) of the vastus lateralis muscle, (b) countermovement jump, (c) maximal isometric SQ contraction, (d) incremental loading SQ test, and (e) fatigue SQ test. All groups significantly increased muscle CSA (p < 0.01, group × time interaction p = 0.18; effect size: VL0: 0.19; VL10: 0.22; VL20: 0.19; VL40: 0.47). Significant group × time interactions were observed for 1RM (p = 0.03) and the velocity attained against heavy loads (p = 0.02), with VL20 obtaining the greatest gains. Effect sizes in the different strength variables were as follows: VL0: 0.50-1.70; VL10: 0.53-2.34; VL20: 0.81-2.72; VL40: 0.52-0.86. Moderate-load resistance training with moderate VL thresholds elicits the greatest strength gains, whereas higher VL thresholds were associated with greater increases in muscle CSA, despite no significant group × time interaction, and yielded comparatively lower strength improvements, highlighting the need to consider VL when applying velocity-based resistance training. PB Wolters Kluwer YR 2026 FD 2026-06-01 LK https://hdl.handle.net/10433/27277 UL https://hdl.handle.net/10433/27277 LA en NO Sánchez-Valdepeñas, J., Cornejo-Daza, P. J., Rodiles-Guerrero, L., Sánchez-Moreno, M., Alegre, L. M., Alcázar, J., & Pareja-Blanco, F. (2026). Mechanical, Neuromuscular, and Hypertrophic Adaptations Through Different Velocity Loss Thresholds With Moderate Loads in Full Squat. Journal of strength and conditioning research, 10.1519/JSC.0000000000005491. Advance online publication. https://doi.org/10.1519/JSC.0000000000005491 NO Fecha de finalización del embargo de acceso: 01 junio 2027 NO Departamento de Deporte e Informática DS RIO RD Aug 5, 2026