RT Journal Article
T1 Kainate receptors: from synaptic activity to disease
A1 Negrete-Díaz, José Vicente
A1 Falcón-Moya, Rafael
A1 Rodríguez-Moreno, Antonio
K1 Kainate receptor
K1 Synaptic activity
K1 Disease
K1 Epilepsy
AB Kainate receptors (KARs) are glutamate receptors that participate in thepostsynaptic transmission of information and in the control of neuronalexcitability, as well as presynaptically modulating the release of the neurotransmittersGABA and glutamate. These modulatory effects, general followa biphasic pattern, with low KA concentrations provoking an increasein GABA and glutamate release, and higher concentrations mediating adecrease in the release of these neurotransmitters. In addition, KARs areinvolved in different forms of long- and short-term plasticity. Importantly,altered activity of these receptors has been implicated in different centralnervous system diseases and disturbances. Here, we describe the pre- andpostsynaptic actions of KARs, and the possible role of these receptors indisease, a field that has seen significant progress in recent years.
PB FEBS Press
YR 2021
FD 2021-06-18
LK http://hdl.handle.net/10433/11424
UL http://hdl.handle.net/10433/11424
LA en
NO FEBS Journal doi: 10.1111/febs.16081
NO Universidad Pablo de Olavide
DS RIO
RD May 23, 2026