%0 Journal Article
%A Negrete-Díaz, José Vicente
%A Falcón-Moya, Rafael
%A Rodríguez-Moreno, Antonio
%T Kainate receptors: from synaptic activity to disease
%D 2021
%U http://hdl.handle.net/10433/11424
%X Kainate receptors (KARs) are glutamate receptors that participate in thepostsynaptic transmission of information and in the control of neuronalexcitability, as well as presynaptically modulating the release of the neurotransmittersGABA and glutamate. These modulatory effects, general followa biphasic pattern, with low KA concentrations provoking an increasein GABA and glutamate release, and higher concentrations mediating adecrease in the release of these neurotransmitters. In addition, KARs areinvolved in different forms of long- and short-term plasticity. Importantly,altered activity of these receptors has been implicated in different centralnervous system diseases and disturbances. Here, we describe the pre- andpostsynaptic actions of KARs, and the possible role of these receptors indisease, a field that has seen significant progress in recent years.
%K Kainate receptor
%K Synaptic activity
%K Disease
%K Epilepsy
%~