RT Journal Article T1 Acute and delayed response to resistance exercise leading or not leading to muscle failure A1 Pareja Blanco, Fernando A1 Rodríguez Rosell, David A1 Sanchez-Medina, L. A1 Ribas-Serna, J. A1 Lopez-Lopez, C. A1 Mora Custodio, Ricardo A1 Yanez-Garcia, J. M. A1 González Badillo, Juan José K1 Heart rate complexity K1 Heart rate variability K1 Hormonal response K1 Neuromuscular fatigue K1 Strength training K1 Velocity-based resistance training AB This study compared the time course of recovery following two resistance exercise protocols differing in the number of repetitions per set with regard to the maximum possible (to failure) number. Ten men performed three sets of 6 versus 12 repetitions with their 70% 1RM (3 9 6 [12] versus 3 9 12 [12]) in the bench press (BP) and squat (SQ) exercises. Mechanical [CMJ height, velocity against the 1 m s 1 load (V1-load)], biochemical [testosterone, cortisol, growth hormone, prolactin, insulin-like growth factor-1, creatine kinase (CK)] and heart rate variability (HRV) and complexity (HRC) were assessed pre-, postexercise (Post) and at 6, 24 and 48 h-Post. Compared with 3 9 6 [12], the 3 9 12 [12]protocol resulted in significantly: higher repetition velocity loss within each set (BP: 65% versus 26%; SQ: 44% versus 20%); reduced V1-load until 24 h-Post (BP) and 6 h-Post (SQ); decreased CMJ height up to 48 h-Post; greater increases in cortisol (Post), prolactin (Post, 48 h-Post) and CK (48 h-Post); and reductions in HRV and HRC at Post. This study shows that the mechanical, neuroendocrine and autonomic cardiovascular response is markedly different when manipulating the number of repetitions per set. Halving the number of repetitions in relation to the maximum number that can be completed serves to minimize fatigue and speed up recovery following resistance training. PB Wiley online library YR 2016 FD 2016-03-11 LK https://hdl.handle.net/10433/22580 UL https://hdl.handle.net/10433/22580 LA en NO Clin Physiol Funct Imaging, 37(6), 630-639 NO FECYT -- VALORACION Y EFECTO DE LA CARGA DE DISTINTOS TIPOS DE ENTRENAMI... NO Departamento de Deporte e informática. Universidad Pablo de Olavide. NO Centro de investigación en rendimiento físico y deportivo DS RIO RD May 1, 2026