RT Journal Article
T1 Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis.
A1 Berná, Genoveva
A1 Oliveras-López, María-Jesús
A1 Jurado Ruiz, Enrique
A1 Tejedo, Juan
A1 Bedoya, Francisco J.
A1 Soria, Bernat
A1 Martín, Franz
K1 Diabetes; ; X; Gene-nutrient interaction
K1 Insulin resistance
K1 Pancreatic β cell
K1 Gene-nutrient interaction
K1 Nutrigenetics
K1 Nutrigenomics
K1 Epigenetics
K1 miRNAs
K1 Nutrients
K1 Dietary patterns
AB Diabetes mellitus (DM) is considered a global pandemic, and the incidence of DM continues to grow worldwide. Nutrients and dietary patterns are central issues in the prevention, development and treatment of this disease. The pathogenesis of DM is not completely understood, but nutrient-gene interactions at different levels, genetic predisposition and dietary factors appear to be involved. Nutritional genomics studies generally focus on dietary patterns according to genetic variations, the role of gene-nutrient interactions, gene-diet-phenotype interactions and epigenetic modifications caused by nutrients; these studies will facilitate an understanding of the early molecular events that occur in DM and will contribute to the identification of better biomarkers and diagnostics tools. In particular, this approach will help to develop tailored diets that maximize the use of nutrients and other functional ingredients present in food, which will aid in the prevention and delay of DM and its complications. This review discusses the current state of nutrigenetics, nutrigenomics and epigenomics research on DM. Here, we provide an overview of the role of gene variants and nutrient interactions, the importance of nutrients and dietary patterns on gene expression, how epigenetic changes and micro RNAs (miRNAs) can alter cellular signaling in response to nutrients and the dietary interventions that may help to prevent the onset of DM.
PB MDPI
YR 2014
FD 2014-11-21
LK https://hdl.handle.net/10433/24987
UL https://hdl.handle.net/10433/24987
LA en
NO Berná, G.; Oliveras-López, M.J.; Jurado-Ruíz, E.; Tejedo, J.; Bedoya, F.; Soria, B.; Martín, F. Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis. Nutrients 2014, 6, 5338-5369. https://doi.org/10.3390/nu6115338
NO Department of Stem Cells, Andalusian Center of Molecular Biology and Regenerative Medicine, University Pablo Olavide (CABIMER-UPO), Seville 41091, Spain
NO Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain
NO Department of Molecular Biology and Biochemistry Engineering, University of Pablo de Olavide of Seville, Seville, Spain
NO Department of Cell Therapy and Regenerative Medicine, Andalusian Center of Molecular Biology and Regenerative Medicine, University Pablo Olavide (CABIMER-UPO), Seville 41091, Spain
DS RIO
RD May 26, 2026