RT Journal Article T1 Approaching study on the relationship between saccharomyces cerevisiae production of tyrosol, hydroxytyrosol, and melatonin with volatile compounds in fermented must A1 González-Ramirez, Marina A1 Marín‑Torres, María Mar A1 Gallardo‑Fernández, Marta A1 Planells‑Carcel, Andrés A1 Bisquert, Ricardo A1 Valero Blanco, Eva María A1 Úbeda, Cristina A1 Troncoso, Ana María A1 García‑Parrilla, María Carmen K1 S. cerevisiae K1 Fermentation K1 Tyrosol K1 Hydroxytyrosol K1 Melatonin K1 Volatile compounds AB Yeasts are feasible and effective bioreactors and, therefore, there is a great interest in their industrial employment for the production of a wide range of molecules. In this study, the production by Saccharomyces cerevisiae of bioactive compounds such as hydroxytyrosol (HT), tyrosol (TYR) and melatonin (MEL) vs. volatile compounds in fermented must was studied. The concentration of the bioactive compounds HT and MEL in fermented must employing different yeast strains revealed that the higher the concentrations, the lower the amount of volatile compounds determined. This inverse correlation was especially remarkable with respect to the production of higher alcohols, especially 2-phenylethanol (2-PE) and esters. Furthermore, the employment of a modified Aro4pK229L S. cerevisiae QA23 yeast strain which overproduces HT, gave rise to fermented must also higher in 2-PE and their corresponding esters but with an outstanding less presence of other important esters such as ethyl hexanoate and ethyl octanoate. Both premises could point out that S. cerevisiae might have differentapproaches to handling cell stress/toxicity due to their nitrogen metabolism. One detoxifying pathway could be through the production of higher alcohols and these in turn to esters and the other be more related to synthesizing antioxidant molecules such as MEL and HT. PB Springer YR 2023 FD 2023-05-25 LK https://hdl.handle.net/10433/25342 UL https://hdl.handle.net/10433/25342 LA en NO Gonzalez-Ramirez, M., Marin-Torres, M.M., Gallardo-Fernandez, M. et al. Approaching Study on the Relationship Between Saccharomyces cerevisiae Production of Tyrosol, Hydroxytyrosol, and Melatonin with Volatile Compounds in Fermented Must. Food Bioprocess Technol 17, 154–168 (2024). https://doi.org/10.1007/s11947-023-03108-y NO Universidad Pablo de Olavide. Departamento de Biología Molecular e Ingeniería Bioquímica DS RIO RD May 9, 2026