RT Journal Article
T1 Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice.
A1 Jurado Ruiz, Enrique
A1 Álvarez Amor, Leticia
A1 Varela Pérez, Lourdes María
A1 Berná, Genoveva
A1 Parra-Camacho, María S.
A1 Oliveras-López, María-Jesús
A1 Martínez-Force, Enrique
A1 Rojas, Anabel
A1 Hmadcha, Abdelkrim
A1 Soria, Bernat
A1 Martín, Franz
K1 Extra virgin olive oil
K1 High fat diet
K1 Type 2 diabetes
K1 Insulin resistance
K1 Pancreatic β-cell
K1 Mice
AB Dietary composition plays an important role in the pathophysiology of type 2 diabetes. Monounsaturated fatty acid consumption has been positively associated with improved insulin sensitivity and β-cell function. We examined whether an extra virgin olive oil (EVOO) high fat diet (HFD) can improve glucose homeostasis. C57BL/6J mice were fed a standard diet or a lard-based HFD to induce type 2 diabetes. Then, HFD mice were fed with three different based HFD (lard, EVOO and EVOO rich in phenolic compounds) for 24 weeks. HFD-EVOO diets significantly improved glycemia, insulinemia, glucose tolerance, insulin sensitivity and insulin degradation. Moreover, EVOO diets reduced β-cell apoptosis, increased β-cell number and normalized islet glucose metabolism and glucose induced insulin secretion. No additional effects were observed by higher levels of phenolic compounds. Thus, EVOO intake regulated glucose homeostasis by improving insulin sensitivity and pancreatic β-cell function, in a type 2 diabetes HFD animal model.
PB Nature
YR 2019
FD 2019-07-25
LK https://hdl.handle.net/10433/24867
UL https://hdl.handle.net/10433/24867
LA en
NO Jurado-Ruiz, E., Álvarez-Amor, L., Varela, L.M. et al. Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice. Sci Rep 9, 11311 (2019). https://doi.org/10.1038/s41598-019-47904-z
NO Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, University Pablo Olavide-University of Seville-CSIC, Seville, Spain
NO Biomedical Research Network on Diabetes and Related Metabolic Diseases- CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain
NO Department of Molecular Biology and Biochemistry Engineering, University Pablo de Olavide (UPO), Seville, Spain.
NO Instituto de la Grasa (CSIC), Campus Universitario Pablo de Olavide, Seville, Spain.
DS RIO
RD May 8, 2026