RT Journal Article
T1 Role of group I metabotropic glutamate receptors in spike timing-dependent plasticity
A1 Martínez Gallego, Irene
A1 Rodríguez-Moreno, Antonio
A1 Andrade Talavera, Yuniesky
K1 STDP
K1 Glutamate receptor
K1 mGluR
K1 Timing
K1 Synaptic plasticity
AB Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit enormous diversity in their expression patterns, sequence homology, pharmacology, biophysical properties and signaling pathways in the brain. In general, mGluRs modulate different traits of neuronal physiology, including excitability and plasticity processes. Particularly, group I mGluRs located at the pre- or postsynaptic compartments are involved in spike timing-dependent plasticity (STDP) at hippocampal and neocortical synapses. Their roles of participating in the underlying mechanisms for detection of activity coincidence in STDP induction are debated, and diverse findings support models involving mGluRs in STDP forms in which NMDARs do not operate as classical postsynaptic coincidence detectors. Here, we briefly review the involvement of group I mGluRs in STDP and their possible role as coincidence detectors.
PB MDPI
YR 2023
FD 2023
LK https://hdl.handle.net/10433/23721
UL https://hdl.handle.net/10433/23721
LA en
NO Martínez-Gallego, I., Rodríguez-Moreno, A., & Andrade-Talavera, Y. (2022). Role of Group I Metabotropic Glutamate Receptors in Spike Timing-Dependent Plasticity. International Journal of Molecular Sciences, 23(14), 7807. https://doi.org/10.3390/ijms23147807
NO Departamento de Fisiología, Anatomía y Biología Celular
DS RIO
RD May 26, 2026