RT Dissertation/Thesis
T1 Respuesta de Schizosaccharomyces pombe a la desestabilización de microtúbulos interfásicos
A1 Romero Balestra, Fernando
K1 Schizosaccharomyces pombe
K1 Ciclo celular
K1 Mitosis
AB Microtubules assume a variety of structures throughout the different stages of the cell cycle. Ensuring the correct assembly of such structures is essential to guarantee cell division. During mitosis, it is well established that the spindle assembly checkpoint monitors the correct attachment of sister chromatids to the mitotic spindle. However, the role that microtubule cytoskeleton integrity plays for cell-cycle progression during interphase is uncertain. Here we describe the existence of a mechanism, independent of the mitotic checkpoint, that delays entry into mitosis in response to G(2)-phase microtubule damage. Disassembly of the G(2)-phase microtubule array leads to the stabilization of the universal mitotic inhibitor Wee1, thus actively delaying entry into mitosis via inhibitory Cdc2 Tyr15 phosphorylation.
YR 2009
FD 2009
LK https://hdl.handle.net/10433/21995
UL https://hdl.handle.net/10433/21995
LA es
NO Programa de Doctorado en Análisis Experimental en Biología
NO Universidad Pablo de Olavide. Departamento de Biología Molecular e Ingeniería Bioquímica
DS RIO
RD May 10, 2026