RT Journal Article
T1 ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the  mouse brain
T2 La microglía que expresa ARG1 muestra una firma molecular distintiva y modula el desarrollo y la función posnatal del cerebro del ratón
A1 Stratoulia, Vassilis
A1 Ruiz, Rocío
A1 Kanatani, Shigeaki
A1 Osman, Ahmed M.
A1 Keane, Lily
A1 Armengol, Jose A.
A1 Rodríguez-Moreno, Antonio
A1 Murgoci, Adriana-Natalia
A1 García-Domínguez, Irene
A1 Alonso-Bellido, Isabel
A1 González Ibáñez, Fernando
A1 Picard, Katherine
A1 Vázquez-Cabrera, Guillermo
A1 Posada-Pérez, Mercedes
A1 Vernoux, Nathalie
A1 Tejera, Dario
A1 Grabert, Kathleen
A1 Cheray, Mathilde
A1 González-Rodríguez, Patricia
A1 Pérez-Villegas, E.
A1 Martínez-Gallego, Irene
A1 Lastra-Romero, Alejandro
A1 Brodin, David
A1 Avila-Cariño, Javier
A1 Cao, Yang
A1 Airavaara, Mikko
A1 Uhlén, Per
A1 Heneka, Michael T.
A1 Tremblay, Marie-Ève
A1 Blomgren, Klas
A1 Venero, Jose L.
A1 Joseph, Bertrand
K1 Microglía
K1 Arginasa-1 (ARG1)
K1 Desarrollo postnatal
K1 Hipocampo
K1 Diversidad molecular
K1 Refinamiento sináptico
AB Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized by the expression of specific proteins constitute subtypes with distinct functions has not been fully elucidated. Here we describe a microglial subtype expressing the enzyme arginase-1 (ARG1; that is, ARG1+ microglia) that is found predominantly in the basal forebrain and ventral striatum during early postnatal mouse development. ARG1+ microglia are enriched in phagocytic inclusions and exhibit a distinct molecular signature, including upregulation of genes such as Apoe, Clec7a, Igf1, Lgals3 and Mgl2, compared to ARG1– microglia. Microglial-specific knockdown of Arg1 results in deficient cholinergic innervation and impaired dendritic spine maturation in the hippocampus where cholinergic neurons project, which in turn results in impaired long-term potentiation and cognitive behavioral deficiencies in female mice. Our results expand on microglia diversity and provide insights into microglia subtype-specific functions.
PB Springer Nature
YR 2023
FD 2023-04-11
LK https://hdl.handle.net/10433/25765
UL https://hdl.handle.net/10433/25765
LA en
NO Nature Neuroscience | Volume 26 | June 2023 | 1008–1020
NO Departamento fisiología, anatomía y biología celular
DS RIO
RD May 30, 2026