RT Journal Article
T1 Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits
A1 Andrade Talavera, Yuniesky
A1 Fisahn, André
A1 Rodríguez-Moreno, Antonio
K1 Neuronal circuit oscillactions
K1 Neuronal network dynamics
K1 Plasticity
K1 STDP
K1 Spikes-synaptic potential coupling
AB In the mammalian brain information processing and storage rely on the complex coding and decoding events performed by neuronal networks. These actions are based on the computational ability of neurons and their functional engagement in neuronal assemblies where precise timing of action potential firing is crucial. Neuronal circuits manage a myriad of spatially and temporally overlapping inputs to compute specific outputs that are proposed to underly memory traces formation, sensory perception, and cognitive behaviors. Spike-timing-dependent plasticity (STDP) and electrical brain rhythms are suggested to underlie such functions while the physiological evidence of assembly structures and mechanisms driving both processes continues to be scarce. Here, we review foundational and current evidence on timing precision and cooperative neuronal electrical activity driving STDP and brain rhythms, their interactions, and the emerging role of glial cells in such processes. We also provide an overview of their cognitive correlates and discuss current limitations and controversies, future perspectives on experimental approaches, and their application in humans.
PB Springer Nature
YR 2023
FD 2023
LK https://hdl.handle.net/10433/23717
UL https://hdl.handle.net/10433/23717
LA en
NO Andrade-Talavera, Y., Fisahn, A. & Rodríguez-Moreno, A. Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits. Mol Psychiatry 28, 2177–2188 (2023). https://doi.org/10.1038/s41380-023-02027-w
NO Departamento de Fisiología, Anatomía y Biología Celular
DS RIO
RD May 26, 2026