RT Journal Article
T1 Bioavailability and systemic transport of oleanolic acid in humans, formulated as a functional olive oil
A1 García-González, Aída
A1 Espinosa-Cabello, Juan Manuel
A1 Cerrillo, Isabel
A1 Montero-Romero, Emilio
A1 Rivas-Melo, Juan José
A1 Romero-Báez, Andrea
A1 Jiménez-Andreu, María Dolores
A1 Ruíz-Trillo, Carmen Amelia
A1 Rodríguez-Rodríguez, Ana
A1 Martínez-Ortega, Antonio Jesús
A1 Roque-Cuellar, María Del Carmen
A1 García-Rey, Silvia
A1 Jiménez-Sánchez, Andrés
A1 Mangas-Cruz, Miguel Ángel
A1 Pereira-Cunill, José Luis
A1 Perona, Javier S.
A1 García-Luna, Pedro Pablo
A1 Castellano, José María
K1 Oleanolic acid
K1 Bioavailability
K1 Olive oil
AB Evidence of the pharmacological activity of oleanolic acid (OA) suggests its potential therapeutic application. However, its use in functional foods, dietary supplements, or nutraceuticals is hindered by limited human bioavailability studies. The BIO-OLTRAD trial is a double-blind, randomized controlled study with 22 participants that received a single dose of 30 mg OA formulated as a functional olive oil. The study revealed that the maximum serum concentration of OA ranged from 500 to 600 ng mL−1, with an AUC0−∞ value of 2862.50 ± 174.50 ng h mL−1. Furthermore, we discovered a physiological association of OA with serum albumin and triglyceride-rich lipoproteins (TRL). UV absorption spectra showed conformational changes in serum albumin due to the formation of an adduct with OA. Additionally, we demonstrated that TRL incorporate OA, reaching a maximum concentration of 140 ng mL−1 after 2–4 hours. We conjecture that both are efficient carriers to reach target tissues and to yield high bioavailability.
PB Royal Society of Chemistry
YR 2023
FD 2023
LK https://hdl.handle.net/10433/22435
UL https://hdl.handle.net/10433/22435
LA en
NO R+D+i project PID2019- 107837RB-I00, funded by the Spanish Ministry of Science and Innovation/Spanish National Research Agency, grant number MCIN/AEI/10.13039/501100011033/
NO Universidad Pablo de Olavide
DS RIO
RD May 9, 2026