RT Patent
T1 Compositions for treating and/or preventing protein-aggregation diseases
T2 Composiciones para tratar y/o prevenir enfermedades de agregación de proteínas
A1 Muñoz Ruiz, Manuel Jesús
A1 Pérez-Jiménez, Mercedes M.
A1 Carrión Rodríguez, Ángel Manuel
K1 STX64
K1 Esteroids sulfatase
K1 Proteostasis lost
K1 Neurodegenerative diseases
K1 Alzheimer disease
AB Proteopathies cover a wide spectrum of afflictions, including neurodegenerative diseases (e.g., Alzheimer's, Parkinson's, polyglutamine diseasessuch as Huntingtin in Huntington's disease, prion diseases); amyloidosis of other non-nervous system proteins such as Į1-antitrypsin, immunoglobulin light and heavy chains, lactadherin, apolipoprotein, gelsolin, lysozyme, fibrinogen, atrial natriuretic factor, keratin, lactoferrin and beta-2 microglobulin, among others); sickle cell disease; cataracts; cystic fibrosis; retinitis pigmentosa; and nephrogenic diabetes insipidus.Surprisingly, the administration of a sulfatase inhibitor is suitableto treat and/or prevent the proteotoxicity commonly associated with proteopathies. The present invention, therefore, provides compositions comprising sulfatase inhibitors for the treatment of proteopathies.
PB Oficina Española de Patentes y Marcas
YR 2023
FD 2023-01-02
LK https://hdl.handle.net/10433/22939
UL https://hdl.handle.net/10433/22939
LA es
NO Universidad Pablo de Olavide
NO Centro Andaluz de Biología del Desarrollo
DS RIO
RD Apr 23, 2026