RT Journal Article T1 Acute Metabolic Response, Neuromuscular Activity, and Mechanical Performance to Different Set A1 Páez Maldonado, José Antonio A1 Cornejo Daza, Pedro Jesús A1 Sánchez-Valdepeñas Mateos-Aparicio, Juan A1 Sánchez-Moreno, Miguel A1 Yuzo-Nakamura, Fábio A1 Pareja Blanco, Fernando A1 Ortega Becerra, Manuel Alejandro K1 Resistance training K1 Lactate K1 Rate of force development K1 Velocity-based training K1 Cluster training AB The aim of this study was to examine the acute metabolic response, neuromuscular activity, and mechanical performance of different set configurations in bench-press (BP). Twenty-two resistance-trained men performed three resistance exercise protocols consisting of 3 x 12 BP repetitions at 60% 1RM, with 4 minutes of rest between sets, but with different set configurations: (a) traditional set (TS), without rest within the set; (b) cluster-6 (CS6), with 30-second intraset rest after the sixth repetition in each set; and (c) cluster-2 (CS2), with 30-second intraset rest every two repetitions. Mean propulsive force (MPF), velocity (MPV), power (MPP), and electromyography (EMG) values were recorded for each repetition. Blood lactate, maximal voluntary isometric BP contraction, and dynamic strength in BP were assessed pre- and post-exercise. The CS2 protocol resulted in greater mechanical performance (i. e. MPF, MPV, and MPP) and lower alterations of EMG parameters (i. e. root mean square and median frequency) during the exercise compared to CS6 and TS (TS