RT Journal Article
T1 Altered Serum Selenium and Uric Acid Levels and Dyslipidemia in Hemodialysis Patients Could be Associated with Enhanced Cardiovascular Risk.
A1 Martí del Moral, Loreto
A1 Agil, Ahmad
A1 Navarro-Alarcón, Miguel
A1 López García de la Serrana, Herminia
A1 Palomares-Bayo, Magdalena
A1 Oliveras-López, María-Jesús
K1 Hemodialysis patients
K1 Selenium
K1 Lipoprotein profile
K1 Uric acid
K1 Longitudinal study
K1 Cardiovascular risk
AB In the present study, the first objective was to follow up serum selenium (Se) concentrations in 117 hemodialysis patients (HPs) during a 2-year longitudinal study, relating concentrations to biochemical indexes (n = 6; namely lipoprotein profile, uric acid, and total protein levels). It was also evaluated whether the disease is associated with an enhanced cardiovascular risk. A healthy control group (n = 50) was also studied. Mean serum Se levels were significantly lower in HPs than in the controls (p = 0.002); mean levels significantly increased from the first to third blood sampling (p < 0.001). HPs showed a marked dyslipidemia, with a significant reduction in total cholesterol, low-density lipoprotein, and high-density lipoprotein cholesterol levels and a significant increase in triglyceride levels (p < 0.001). HPs showed a marked hyperuricemia (p < 0.001). Serum selenium levels in HPs were correlated negatively with uric acid levels (inflammation biomarker; p < 0.01). In HPs, serum Se levels are reduced due to their disease (chronic renal failure). Serum Se levels rose until the third blood sampling. The marked dyslipidemia and hyperuricemia found in HPs and the negative correlation between the serum Se and uric acid levels in these patients could imply an enhanced cardiovascular risk.
PB Springer
YR 2011
FD 2011-07-13
LK https://hdl.handle.net/10433/24910
UL https://hdl.handle.net/10433/24910
LA en
NO Martí del Moral, L., Agil, A., Navarro-Alarcón, M. et al. Altered Serum Selenium and Uric Acid Levels and Dyslipidemia in Hemodialysis Patients Could be Associated with Enhanced Cardiovascular Risk. Biol Trace Elem Res 144, 496–503 (2011). https://doi.org/10.1007/s12011-011-9152-4
NO Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
NO Institute of Neurosciences, Department of Pharmacology, School of Medicine, University of Granada, 18071 Granada, Spain
NO Hemodialysis Department, Guadix Hospital, Granada, Spain
NO Department of Molecular Biology and Biochemical Engineering, University of Pablo de Olavide of Seville, 41013 Seville, Spain
DS RIO
RD May 6, 2026