RT Journal Article
T1 Coenzyme Q10 levels associated with cognitive functioning and executive function in older adults
A1 Fernández-Portero, Cristina
A1 García Amián, Josué
A1 De la Bella, Rocío
A1 López-Lluch, Guillermo
A1 Alarcón, David
K1 Coenzyme Q10
K1 Cognitive functioning
K1 Executive function
K1 Oxidative stress
AB Brain deterioration with age is associated with inflammation and oxidative stress that result in structural and functional changes. Recent studies have indicated that coenzyme Q10 (CoQ10) is associated with neurological oxidative stress and cognitive impairment. Studies with older people have shown a relationship between neurodegenerative diseases and CoQ10 levels. However, no studies have analyzed the relationship between CoQ10 and cognitive functioning in older adults. The aim of this study was to analyze the association between CoQ10 and cognitive functioning in an older adult sample, controlling for other factors that may influence aging, such as the level of physical activity and nutritional status. The sample consisted of 64 older adults aged 65–99 years (76.67 ± 8.16 years), among whom 48 were women (75%). The participants were recruited among those who attended community centers to voluntarily participate in leisure activities. According to previous studies, physical activity and nutritional status are positively associated with cognitive functioning. However, the main finding of this study was that plasma CoQ10, controlling for other measures, was significantly associated with cognitive functioning and executive function. The current findings suggest that a decline in cognitive capacities may be related to reduced antioxidant defenses, as reflected by low CoQ10 levels in older adults.
PB Oxford Academic
YR 2022
FD 2022-07-31
LK https://hdl.handle.net/10433/22325
UL https://hdl.handle.net/10433/22325
LA en
NO Fernández-Portero C, Amián JG, Bella R, López-Lluch G, Alarcón D. Coenzyme Q10 Levels Associated With Cognitive Functioning and Executive Function in Older Adults. J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78(1):1-8. doi: 10.1093/gerona/glac152. PMID: 35908233.
NO Department of Social Anthropology, Psychology and Public Health
DS RIO
RD May 9, 2026