RT Journal Article
T1 Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development
A1 Falcón Moya, Rafael
A1 Pérez Rodríguez, Mikel
A1 Prius Mengual, José
A1 Andrade Talavera, Yuniesky
A1 Arroyo García, Luis Enrique
A1 Pérez Artés, Rocío
A1 Mateos-Aparicio Moreno, Pedro
A1 Guerra Gómes, Sonia
A1 Oliveira, João Filipe
A1 Flores Álvarez, Gonzalo
A1 Rodríguez-Moreno, Antonio
K1 STDP
K1 Hippocampus
K1 Astrocytes
K1 NMDA receptors
K1 Developmental plasticity
AB Presynaptic spike timing-dependent long-term depression (t-LTD) at hippocampal CA3-CA1 synapses is evident until the 3rd postnatal week in mice, disappearing during the 4th week. At more mature stages, we found that the protocol that induced t-LTD induced t-LTP. We characterized this form of t-LTP and the mechanisms involved in its induction, as well as that driving this switch from t-LTD to t-LTP. We found that this t-LTP is expressed presynaptically at CA3-CA1 synapses, as witnessed by coefficient of variation, number of failures, paired-pulse ratio and miniature responses analysis. Additionally, this form of presynaptic t-LTP does not require NMDARs but the activation of mGluRs and the entry of Ca2+ into the postsynaptic neuron through L-type voltage-dependent Ca2+ channels and the release of Ca2+ from intracellular stores. Nitric oxide is also required as a messenger from the postsynaptic neuron. Crucially, the release of adenosine and glutamate by astrocytes is required for t-LTP induction and for the switch from t-LTD to t-LTP. Thus, we have discovered a developmental switch of synaptic transmission from t-LTD to t-LTP at hippocampal CA3-CA1 synapses in which astrocytes play a central role and revealed a form of presynaptic LTP and the rules for its induction.
PB Nature Publishing Group
YR 2020
FD 2020
LK https://hdl.handle.net/10433/23722
UL https://hdl.handle.net/10433/23722
LA en
NO Falcón-Moya, R., Pérez-Rodríguez, M., Prius-Mengual, J. et al. Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development. Nat Commun 11, 4388 (2020). https://doi.org/10.1038/s41467-020-18024-4
NO Departamento de Fisiología, Anatomía y Biología Celular
DS RIO
RD May 26, 2026