%0 Journal Article
%A Falcón Moya, Rafael
%A Pérez Rodríguez, Mikel
%A Prius Mengual, José
%A Andrade Talavera, Yuniesky
%A Arroyo García, Luis Enrique
%A Pérez Artés, Rocío
%A Mateos-Aparicio Moreno, Pedro
%A Guerra Gómes, Sonia
%A Oliveira, João Filipe
%A Flores Álvarez, Gonzalo
%A Rodríguez-Moreno, Antonio
%T Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development
%D 2020
%U https://hdl.handle.net/10433/23722
%X Presynaptic spike timing-dependent long-term depression (t-LTD) at hippocampal CA3-CA1 synapses is evident until the 3rd postnatal week in mice, disappearing during the 4th week. At more mature stages, we found that the protocol that induced t-LTD induced t-LTP. We characterized this form of t-LTP and the mechanisms involved in its induction, as well as that driving this switch from t-LTD to t-LTP. We found that this t-LTP is expressed presynaptically at CA3-CA1 synapses, as witnessed by coefficient of variation, number of failures, paired-pulse ratio and miniature responses analysis. Additionally, this form of presynaptic t-LTP does not require NMDARs but the activation of mGluRs and the entry of Ca2+ into the postsynaptic neuron through L-type voltage-dependent Ca2+ channels and the release of Ca2+ from intracellular stores. Nitric oxide is also required as a messenger from the postsynaptic neuron. Crucially, the release of adenosine and glutamate by astrocytes is required for t-LTP induction and for the switch from t-LTD to t-LTP. Thus, we have discovered a developmental switch of synaptic transmission from t-LTD to t-LTP at hippocampal CA3-CA1 synapses in which astrocytes play a central role and revealed a form of presynaptic LTP and the rules for its induction.
%K STDP
%K Hippocampus
%K Astrocytes
%K NMDA receptors
%K Developmental plasticity
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