RT Journal Article
T1 Cytotoxic and mutagenic in vitro assessment of two organosulfur compounds derived from onion to be used in the food industry
A1 Llana Ruíz-Cabello, María
A1 Maisanaba, Sara
A1 Gutiérrez-Praena, Daniel
A1 Prieto, Ana Isabel
A1 Pichardo, Silvia
A1 Jos, Angeles
A1 Moreno, Francisco Javier
A1 Cameán, Ana María
K1 Dipropyl disulphide
K1 Caco-2 cell line
AB Edible members of the Allium family are widely used since they exhibit antioxidant and antibacterialrelated to the organosulphur compounds. One the most promising use of Allium species, hence, onionessential oil, could be in the packaging food industry. The present work aims to assess the safety oftwo organosulphur compounds present in onion essential oil; dipropyl disulphide, dipropyl sulphideand their mixture. For this purpose, cytotoxicity, reactive oxygen species and glutathione contents, andultrastructural cellular damages were studied in the human intestinal cells, Caco-2, exposed to theseorganosulphur compounds. Moreover, their potential mutagenicity was also assessed. The resultsrevealed no significant adverse effects. Additionally, reactive oxygen species scavenger activity wasobserved for both compounds. Therefore, they could be a good natural alternative to other syntheticantioxidant and antibacterial substances used in the food industry.
PB Elsevier
YR 2014
FD 2014-06-16
LK https://hdl.handle.net/10433/19838
UL https://hdl.handle.net/10433/19838
LA en
NO -	Cytotoxic and mutagenic in vitro assessment of two organosulfur compounds derived from onion to be used in the food industry. Llana-Ruiz-Cabello, M., Maisanaba, S., Gutiérrez-Praena, D., Prieto, A.I., Pichardo, S., Jos, A., Moreno, F.J., Cameán, A.M. Food Chemistry, 2015, 166, pp. 423–431.
NO Proyectos de investigaciónFECYT -- EVALUACION DE LA SEGURIDAD PARA CONTACTO ALIMENTARIO DE ENVASES...AGR-7252
NO Area of Toxicology, Faculty of Pharmacy, Universidad de Sevilla
NO Area of Cellular Biology, Faculty of Biology, Universidad de Sevilla,
DS RIO
RD May 26, 2026