RT Journal Article
T1 L1 retrotransposition alters the hippocampal genomic landscape enabling memory formation
A1 Bachiller Sanchez Arevalo, Sara
A1 Yaiza Del-Pozo-Martín, 
A1 Carrión Rodríguez, Ángel Manuel
K1 Gene expression
K1 Hippocampus
K1 LINE1
K1 Memory formation
K1 Retrotransposition
AB Somatic LINE-1 (L1) retrotransposition is a source of genomic mosaicism and potential phenotypic diversity among neurons during brain development. In the adult brain, L1 expression can be triggered by different environmental alterations, but its functional role in this context remains unknown. Here we demonstrate a neural activation-dependent increase in the number of L1 retrotransposon insertions in the hippocampus. Using both pharmacologic and genetic approaches in mice, we demonstrate that L1 expression in the adult hippocampus enables long-term memory formation. These results provide experimental evidence that L1 retrotransposition-induced genomic mosaicism is involved in cognitive processes such as memory formation.
PB Elsevier
YR 2017
FD 2017
LK https://hdl.handle.net/10433/23065
UL https://hdl.handle.net/10433/23065
LA en
NO Bachiller S, Del-Pozo-Martín Y, Carrión ÁM. L1 retrotransposition alters the hippocampal genomic landscape enabling memory formation. Brain Behaviour and  Immunity. 2017 Aug;64:65-70
NO Fundación Ramón Areces – Spain and DGICYT – Spain (Departamento Gubernamental de Investigaciones Científicas y Tecnológicas: BFU2008-01552 and BFU2011-27207)
NO Departamento de Fisiología, Anatomía y Biología Celular
DS RIO
RD May 13, 2026