RT Journal Article
T1 The claustrum is involved in cognitive processes related to the classical conditioning of eyelid responses in behaving rabbits
A1 Reus-García, M. Mar
A1 Sánchez-Campusano, Raudel
A1 Ledderose, J.
A1 Dogbevia, G.K.
A1 Treviño, M.
A1 Hasan, M.T.
A1 Gruart, Agnès
A1 Delgado-García, J.M.
K1 Claustrum
K1 Classical eyeblink conditioning
K1 Local Field Potentials
K1 Rabbits
K1 Unitary recording
K1 Virus-delivered inducible silencing of synaptic transmission
AB It is assumed that the claustrum (CL) is involved in sensorimotor integration and cognitive processes.We recorded the firing activity of identified CL neurons during classical eyeblink conditioning in rabbits, using a delay paradigm in which a tone was presented as conditioned stimulus (CS), followed by a corneal air puff as unconditioned stimulus (US). Neurons were identified by their activation from motor (MC), cingulate (CC), and medial prefrontal (mPFC) cortices. CL neurons were rarely activated by single stimuli of any modality. In contrast, their firing was significantly modulated during the first sessions of paired CS/US presentations, but not in well-trained animals. Neuron firing rates did not correlate with thekinematics of conditioned responses (CRs). CL local field potentials (LFPs) changed their spectral power across learning and presented well-differentiated CL–mPFC/CL–MC network dynamics, as shown by crossfrequency spectral measurements. CL electrical stimulation did not evoke eyelid responses, even in trained animals. Silencing of synaptic transmission of CL neurons by the vINSIST method delayed the acquisition of CRs but did not affect their presentation rate. The CL plays an important role in the acquisition of associative learning,mostly in relation to the novelty of CS/US association, but not in the expression of CRs.
PB Oxford University Press
YR 2021
FD 2021-01
LK https://hdl.handle.net/10433/19870
UL https://hdl.handle.net/10433/19870
LA en
NO Cerebral Cortex, vol 31, nº 1, p. 281-300
NO El estudio ha permitido concluir que el claustro cumple un importante papel en las funciones cognitivas cerebrales, sobre todo en los aspectos referentes a la novedad, relevancia e importancia vital de los estímulos sensoriales presentes en nuestro entorno. Al mismo tiempo, el estudio sugiere que en los procesos cognitivos intervienen de forma coordinada otras estructuras cerebrales, aparte del claustro. Este pionero experimento abre camino para ulteriores estudios relacionados con la actividad cerebral que subyace a los procesos mentales y cognitivos.
NO MINECO-BFU2017-82375-R
NO Departamento de Fisiología, Anatomía y Biología Celular
DS RIO
RD Apr 24, 2026