CyEnGNet—App: A new Cytoscape app for the reconstruction of large co-expression networks using an ensemble approach

Abstract

The construction of gene co-expression networks is an essential tool in Bioinformatics for discovering useful biological knowledge. There are a multitude of methodologies related to the construction of this type of network, and one of them is EnGNet, which carries out a joint and greedy approach to the reconstruction of large gene coexpression networks. This work introduces CyEnGNet-App, a Cytoscape application designed to integrate and leverage the EnGNet algorithm. The application allows dynamic interaction and visualisation of gene networks and integration with other Cytoscape applications. CyEnGNet-App is a valuable addition to the field of Bioinformatics, improving the reconstruction of genetic networks and providing a more accessible and efficient user experience in Cytoscape.