Quercetin supplementation promotes recovery after exercise-induced muscle damage: a systematic review and meta-analysis of randomized controlled trials

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Peña-Amaro, José
Berral de la Rosa, Francisco José
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Termedia Publishing
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Quercetin (Q) is one of the most frequently consumed flavonoids in the human diet. The purpose of this systematic review and meta-analysis was to determine the effects of Q supplementation on muscle damage, muscle soreness and biochemical markers of inflammation, antioxidant capacity and oxidative stress after intense exercise. A literature search of SPORTDiscus, PubMed, Web of Science and Scopus was performed from inception to May 31, 2022. Forest plots were generated with fixed or random-effect models and standardized mean differences (SMD). Data extraction and quality assessment were performed independently by two authors. After application of the inclusion and exclusion criteria, 13 studies with a total of 249 sedentary to well-trained participants were included. For all studies there were some concerns about the risk of bias. All but one study used a supplementation dosage of 1000 mg/day. Q supplementation accelerated recovery of muscle function and significantly decreased muscle soreness 0/24 h after exercise (SMD: -1.33; p = 0.03), creatine kinase levels 24/48 h after exercise (SMD: -1.15; p = 0.02), and post-exercise oxidative stress (SMD: -0.92; p = 0.03). However, Q supplementation had no effect on IL-6 concentration. Q supplementation with a dose of 1000 mg/day for periods of more than seven days and a maximum of 12 weeks appears to be a safe and efficacious strategy to reduce muscle damage and muscle soreness, as well as to enhance recovery after intense exercise in sedentary to well-trained young men. Systematic review registration: PROSPERO CRD42021266801.
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Convocatoria de Ayudas para la realización de Proyectos en el Ámbito Tecnológico del Deporte Profesional, convocadas por el Departamento Tecnológico de la Empresa YSANA SL, empresa dedicada al campo de los suplementos nutricionales y productos farmacéuticos. Convocatoria de fecha 23 de Marzo de 2020. *PROYECTO: DESARROLLO E IMPLEMENTACION DE UNA PLATAFORMA DE COMUNICACIÓN ONLINE, DE PARAMETROS NUTRICIONALES, DEPORTIVOS Y CULINARIOS APLICADOS AL DEPORTE PROFESIONAL. Institución que conceden la subvención: YSANA SL. (Italia). Departamento Tecnológico. Nº ref. PATDF/Y. Subvención: 11.253 euros. Cantidad destinada al desarrollo de una herramienta online para el proceso de consulta y seguimiento de profesionales del deporte. Centros de Ejecución: Departamento de Nutrición del Udinese Calcio Spa y Departamento de Deporte e Informática de la Universidad Pablo de Olavide de Sevilla. Grupo de Investigación y Desarrollo Tecnológico denominado "EJERCICIO, SALUD Y ALTO RENDIMIENTO", con código CTS-595. Junta de Andalucía. Consejería de Innovación, Ciencia y Empresa. Secretaría General de Universidades, Investigación y Tecnología. Periodo de Ejecución: 2 de abril de 2020 de 2019 al 9 de mayo de 2020. Investigador principal: Lcdo. D. Antonio Molina López Investigadores: Lcdo. D. Heliodoro Moya Amaya Dr. D. Antonio Jesús Berral Aguilar Dr. D. Daniel Rojano Ortega Dr. D. Francisco José Berral de la Rosa Total de investigadores: 5
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Rojano-Ortega D, Peña-Amaro J, Berral-Aguilar AJ, Berral-de la Rosa FJ. Quercetin supplementation promotes recovery after exercise-induced muscle damage: a systematic review and meta-analysis of randomized controlled trials. Biology of Sport (Biol Sport) 2023; 40(3):813-825. ISSN: 0860-021X eISSN: 2083-1862 DOI:
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